⚠️ ¡Atención! Esta información está dirigida a profesionales de la salud. Si vives en Chile y necesitas una consulta médica para evaluar si necesitas PEP para VIH o DoxyPEP, háblame por WhatsApp.
Es esencial abordar y difundir la evidencia científica que sustenta el uso de la profilaxis post-exposición no ocupacional (PEP-VIH y DoxyPEP) con el objetivo de mejorar la calidad de atención a las personas que requieren utilizar este método. Este artículo ofrece enlaces a importantes recursos sobre este tópico, tanto a la evidencia que lo sustenta como a las recomendaciones oficiales de organismos de salud pública.
Profilaxis post-exposición (PEP) para VIH
Guías clínicas
- DESTACADA! BHIVA (2023). UK guideline for the use of HIV post-exposure prophylaxis 2021. Post consultation version, 2023 amendment. https://www.bhiva.org/file/6183b6aa93a4e/PEP-guidelines.pdf
- Son las guías más completas que están disponibles acerca de la PEP.
- World Health Organization (2014). Guidelines on Post-Exposure Prophylaxis for HIV and the use of Co-trimoxazole prophylaxis for HIV-related infections among adults, adolescentes and children: recommendations for a public health approach. http://apps.who.int/iris/bitstream/10665/145719/1/9789241508193_eng.pdf?ua=1
- Ministerio de Salud, Chile (2016). Norma general técnica para la atención de víctimas de violencia sexual. https://diprece.minsal.cl/wrdprss_minsal/wp-content/uploads/2016/10/NT_VICTIMAS-VIOLENCIA-SEXUAL_web.pdf
Estudios clínicos
- Bryant J, et al. (2009) Non-occupational postexposure prophylaxis for HIV: a systematic review. Health Technol Assess; 13(14):iii, ix-x, 1-60. doi: 10.3310/hta13140.
- Landovitz RJ, Currier JS. (2009) Clinical practice. Postexposure prophylaxis for HIV infection. N Engl J Med; 361(18): 1768-75. doi: 10.1056/NEJMcp0904189.
- Roland ME. (2007) Postexposure prophylaxis after sexual exposure to HIV. Curr Opin Infect Dis; 20(1): 39-46. doi: 10.1097/QCO.0b013e328012c5e0.
DoxyPEP
Guías clínicas
- NUEVA! U.S. Centers for Disease Control and Prevention (2024). CDC Clinical Guidelines on the Use of Doxycycline Postexposure Prophylaxis for Bacterial Sexually Transmitted Infection Prevention, United States. https://www.cdc.gov/mmwr/volumes/73/rr/pdfs/rr7302a1-H.pdf
- Son las guías clínicas más recientes sobre DoxyPEP y las primeras emitidas por una entidad nacional encargada de la salud pública.
- California Department of Public Health (2023). Doxycycline Post-Exposure Prophylaxis (doxy-PEP) for the Prevention of Bacterial Sexually Transmitted Infections (STIs). https://www.cdph.ca.gov/Programs/CID/DCDC/CDPH%20Document%20Library/CDPH-Doxy-PEP-Recommendations-for-Prevention-of-STIs.pdf
- Seattle & King County Public Health (2023). Doxycycline Post-Exposure Prophylaxis (Doxy-PEP) to Prevent Bacterial STIs in Men who Have Sex with Men (MSM) and Transgender Persons who Have Sex with Men. https://cdn.kingcounty.gov/-/media/depts/health/communicable-diseases/documents/hivstd/DoxyPEP-Guidelines.ashx
- San Francisco Departament of Public Health (2022). Health Update: Doxycycline Post-Exposure Prophylaxis Reduces Incidence of Sexually Transmitted Infections. https://www.sfcdcp.org/wp-content/uploads/2022/10/Health-Update-Doxycycline-Post-Exposure-Prophylaxis-Reduces-Incidence-of-Sexually-Transmitted-Infections-SFDPH-FINAL-10.20.2022.pdf
Estudios clínicos
- Hyman S, et al. (2024) Doxycycline PEP: High Uptake and Significant Decline in STIs After Clinical Implementation. CROI 2024. https://www.croiconference.org/abstract/doxycycline-pep-high-uptake-and-significant-decline-in-stis-after-clinical-implementation/
- Luetkemayer A, et al. (2024) Sustained Reduction of Bacterial STIs During the DoxyPEP Study Open-Label Extension. CROI 2024. https://www.croiconference.org/abstract/sustained-reduction-of-bacterial-stis-during-the-doxypep-study-open-label-extension/
- Luetkemayer A, et al. (2024) DoxyPEP & antimicrobial resistance in N. gonorrhoeae, commensal Neisseria & S. aureus. CROI 2024. https://www.croiconference.org/abstract/doxypep-antimicrobial-resistance-in-n-gonorrhoeae-commensal-neisseria-s-aureus/
- Sankaran M, et al. (2024) Doxy-PEP Associated With Declines in Chlamydia and Syphilis in MSM and Trans Women in San Francisco. CROI 2024. https://www.croiconference.org/abstract/doxy-pep-associated-with-declines-in-chlamydia-and-syphilis-in-msm-and-trans-women-in-san-francisco/
- Luetkemeyer A, et al. (2023) Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections. N Engl J Med; 388(14): 1296-1306, doi: 10.1056/NEJMoa2211934.
- Molina JM, et al. (2023) ANRS 174 DoxyVAC: An open-label randomized trial to prevent STIs in MSM on PrEP. CROI 2023, 19-22 de febrero, 2023, Seattle. Abstract 119. https://www.croiconference.org/abstract/anrs-174-doxyvac-an-open-label-randomized-trial-to-prevent-stis-in-msm-on-prep/
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